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Wexford Science & Technology Begins Renovation of Historic St. Louis Building Into Sustainable, Multi-Tenant Lab, and Research Facility 


$73 million project, scheduled to be completed by late 2013, will be a center for
innovation and entrepreneurism in technology and life sciences

ST. LOUIS (May 16, 2013) – Wexford Science & Technology, LLC,  a private real estate development and investment company, is transforming the historic Heritage Building in the CORTEX District in St. Louis’ popular Central West End into a state-of-the-art, sustainable, multi-tenant laboratory and research facility.  Construction of this new facility, to be complete by late 2013 and renamed @4240, kicks off Phase II development in the CORTEX District.  This $73 million building at the corner of Duncan and Boyle will attract national research organizations and will be home to approximately 457 full-time research, technology and related jobs.  As an anchor tenant, Washington University in St. Louis will lease 69,000 square feet of space for its Offices of Technology Management, Research Administration and faculty practice plan. Additional lab and office space are available for lease.

Wexford Science & Technology, LLC is a Baltimore-based development company that collaborates with leading universities, research institutions, and healthcare systems to create and build Knowledge Communities – vibrant, mixed-use, amenity-rich environments that integrate academic, corporate, and entrepreneurial research and development activities.  Wexford currently has developed eight additional knowledge communities across the U.S.

“@4240 will provide St. Louis with multi-tenant lab and research space that rivals any other center of research in the United States,” said Dan Cramer, Executive Vice President – Wexford Science & Technology, LLC.  “The property will have the capabilities and infrastructure to support a variety of types of research from small start-ups to established corporate users from around the country looking to relocate to or expand in St. Louis.”

“Wexford’s commitment in transforming an historic property to a place for research and discovery makes it a unique design project in itself,” said David Chassin of HOK, architects for the redevelopment project.  “Challenges are inherent for these type of projects; not only are we rehabilitating an historic building, we had to make it flexible to support different types of research and be energy-efficient to achieve the highest possible level of LEED® certification by the U.S. Green Building Council®.  It’s an ambitious project, and we’re building it right here in the heart of St. Louis.”

“@4240 puts the CORTEX District on a competitive playing field with other research districts across the country.  It makes St. Louis even more attractive to national companies,” said Dennis Lower, President and CEO of CORTEX.  “It’s amazing to look out my CORTEX I window and see an old Southwestern Bell telephone factory transform into a high tech research facility – and know it will house nearly 500 high tech jobs in the heart of our city.”

“A great CORTEX research district is critical to our institution, the city of St. Louis, and the entire region,” said Hank Webber, Executive Vice Chancellor for Administration at Washington University in St. Louis. “Our great hope is that our presence in this new space in @4240 will lead to a major increase in startup business activity and a more rapid movement of innovations developed by our faculty and students into the marketplace. This will fuel the region’s economy and improve our overall quality of life.”


Building Highlights

Heritage Building Currently

The 183,000 square foot building will be transformed to meet the needs of research, biotech, technology innovation and science-based tenants.  “Natural light is a key factor in the overall aesthetic of the renovation,” said HOK’s Science + Technology discipline group leader, Joseph Ostafi.  “The design maximizes natural light by using large, industrial windows throughout the space so all labs and office tenants will have daylight.  We also added skylights and light shafts so concourses and common areas on the lower floors will have natural lighting.”

The St. Louis-headquartered design-construction team of HOK and Tarlton Corp. is replicating the original design of the more than 500 large, industrial windows and replacing the inefficient steel frames with aluminum and insulated glass.

Proposed Rendered Changes

Another tenant-pleasing feature of @4240 will be the central concourse, which will run through the building north to south, connecting the first and second floors and creating a common collaboration area with skylights lining the roof.

Washington University’s Offices of Technology Management and Research Administration will take space in the old factory’s garage area, where HOK and Tarlton are taking advantage of a unique roof monitor skylight to create dynamic office space filled with natural light.

The main entrance of @4240 will be moved from Duncan Avenue to Boyle Avenue to face the new CORTEX Commons, a park-like open space that will serve as a hub for the entire CORTEX District.  The Commons will include a landscaped plaza, giving tenants an area for outdoor seating.  The CORTEX district will soon begin work on new streets, sidewalks, street trees, lighting and public safety enhancements that will be completed alongside @4240.


Wexford will register @4240 with the highest possible LEED certification goal based on significant construction restoration to the historical building and the many sustainable design features, including energy recovery ventilation, permeable pavements, low-watering native landscaping, high performance windows, and photovoltaic panels on the roof.  Display panels in the building lobby will show the solar panel’s generations of energy and @4240’s energy usage in real time.

About Wexford Science & Technology

Wexford Science and Technology LogoWexford Science & Technology, LLC is a private real estate investment and development company that meets the growing and specialized facilities needs of for-profit and not-for-profit institutions including universities, university-related research parks and healthcare systems.  Wexford creates and builds Knowledge Communities – vibrant, mixed-use, amenity-rich environments where innovation thrives.  Wexford is building eight other Knowledge Communities across the U.S: the Bio-Research & Development Growth (BRDG) Park at the Danforth Plant Science Center in St. Louis; Hershey Center for Applied Research in Hershey, PA; Innovation Research Park at Old Dominion University in Norfolk, VA; University City Science Center in Philadelphia; University of Maryland BioPark in Baltimore; University of Miami Life Science & Technology Park in Miami; University Technology Park at IIT in Chicago; and Wake Forest Biotech Place at the Wake Forest Innovative Quarter in Winston-Salem, NC. Wexford recently announced a merger with life science giant, BioMed Realty Trust, Inc., a $4 billion real estate investment trust based in San Diego, California.


Five premier educational and research institutions joined forces in 2004 to create CORTEX, a not-for-profit organization.  With their initiative, and ever-expanding community support, CORTEX is destined to become the regional and national hub for life sciences research, development and commercialization.

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